Oswalt has appeared in many films, including the film adaptation of Dave Eggers’ novel THE CIRCLE, alongside Tom Hanks and Emma Watson, THE SECRET LIFE OF WALTER MITTY, with Ben Stiller, Steven Soderbergh’s THE INFORMANT, alongside Seth Rogen in OBSERVE AND REPORT, in Paul Thomas Anderson’s MAGNOLIA, ZOOLANDER, STARSKY AND HUTCH, and RENO 911!: MIAMI, among many others.

He also provided the voice for ‘Remy’ the rat, in Pixar’s Oscar-winning RATATOUILLE, and played one of the “white voices” in the widely-praised indie film SORRY TO BOTHER YOU, the directorial debut of Boots Riley; Oswalt also voiced the titular character on the hit SYFY series “Happy!” as well as characters on other TV shows such as “Archer,” “BoJack Horseman,” “The Simpsons,” “Bob’s Burgers,” “Aqua Teen Hunger Force,” and “Word Girl.”  He is also the narrator on ABC’s hit comedy “The Goldbergs.”

On TV, Oswalt had a starring role on Adult Swim’s “The Heart, She Holler,” was a series regular on Showtime’s “United States of Tara” and the Netflix revival of “Mystery Science Theater 3000,” recurred on the SyFy series “Caprica,” and has had many guest roles on “Veep,” “Lady Dynamite,” “Agents of S.H.I.E.L.D.,” “Parks and Recreation,” “Justified,” “Two and a Half Men,” “Portlandia,” “Bored to Death,” “Flight of the Conchords,” The Sarah Silverman Program,” “Tim and Eric’s Awesome Show,” and “Seinfeld,” among others.   He is also very well known for playing ‘Spence’ on “The King of Queens” for nine seasons.  He was also a regular contributor to “Countdown with Keith Olbermann,” “Real Time with Bill Maher,” and Lewis Black’s “Root of All Evil.”

As a comedian, Oswalt has shot eight TV specials and released seven critically acclaimed albums, including his Grammy-winning Talking for Clapping (which the one-hour special of the same name earned him an Emmy) and Grammy-nominated Tragedy Plus Comedy Equals Time that debuted in 2014. Finest Hour also received a Grammy nomination for “Best Comedy Album,” as well as a Showtime one-hour special of the same name. In 2009, Patton received his first Grammy nomination for his album My Weakness Is Strong (Warner Brothers Records).

Oswalt starred in The Comedians of Comedy, which was shot as an independent feature film, a TV series and a long running tour. He tours regularly and extensively, headlining both in the United States, Canada, and the UK. Oswalt also had a regular, bi-monthly show at the new Largo at the Coronet Theater in Los Angeles.

Both of his published books Zombie Spaceship Wasteland (2011) and Silver Screen Fiend (2015) are New York Times Best Sellers.   In 2018, Oswalt helped publish his late wife Michelle McNamara’s true-crime book I’ll Be Gone in the Dark (The New York Times Best Seller) and he executive produced the HBO docuseries based on the book about the Golden State Killer.